The cytotoxic effects of organophosphorus compound dichlorvos and of its commercial formulations

Abstract

The cytotoxic effects of organophosphorus compound dichlorvos and of its commercial formulations Nuvan — 50 and Nogos — 50, both produced and in use in Yugoslavia, were comparatively studied. Saccharomyces cerevisiae N 123 yeast strain served as a test organism. Yeasts were incubated in a complete nutrient medium containing the pesticide in a concentration range from 0.125 to 12.0 mg/ml of active substance. The cytotoxic effect was determined as the degree of inhibited cell division during and after 26-hour incubation at 28°C. According to results the original form of dichlorvos is more toxic than the two commercial formulations, and so is Nuvan-50 compared to Nogos-50. In our experimental conditions no increase of tolerance of the microorganism to the pesticide or the reversibility of the effect after treat­ ment with high pesticide concentrations could be establi­ shed. It may be concluded that the effect of the active sub­ stance, dichlorvos, is modified in formulations more in terms of intensity rather than in the mode of action.

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